2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide
- Product Name
- 2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide
- CAS No.
- 383432-38-0
- Chemical Name
- 2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide
- Synonyms
- 714;CP724;CP-724;CP 724;CS-2306;CP-724714（b）;CP 724714 NEW;CP-724714 (E-Double bond);CP 724714;CP724714;CP-724714 (E-DOUBLE BOND);CP-724;714;CP724;714;CP 724714;CP 724;714;CP724714;CP-724714
- CBNumber
- CB92484874
- Molecular Formula
- C27H27N5O3
- Formula Weight
- 469.54
- MOL File
- 383432-38-0.mol
2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide Property
- Boiling point:
- 687.3±55.0 °C(Predicted)
- Density
- 1.251
- storage temp.
- Store at -20°C
- solubility
- DMF: 3 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 3 mg/ml; Ethanol: 2 mg/ml
- form
- A crystalline solid
- pka
- 13.95±0.46(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- PZ0335
- Product name
- CP724714
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $108
- Updated
- 2024/03/01
- Product number
- PZ0335
- Product name
- CP724714
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $435
- Updated
- 2024/03/01
- Product number
- 19172
- Product name
- CP 724,714
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 19172
- Product name
- CP 724,714
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $142
- Updated
- 2024/03/01
- Product number
- 19172
- Product name
- CP 724,714
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $266
- Updated
- 2024/03/01
2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide Chemical Properties,Usage,Production
Description
CP 724,714 is a selective inhibitor of HER2/ErbB2 with an IC50 value of 10 nM. It demonstrates greater than 640-fold selectivity against EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, and c-Met. CP 724,714 has been shown to inhibit the proliferation of ErbB2-amplified cells, including BT474 and SK-BR-3 with IC50 values of 0.25 and 0.95 μM, respectively. It also demonstrates antitumor activity in various human tumor xenograft models. However, CP 724,714 was discontinued from clinical development due to hepatotoxicity caused by its ability to inhibit hepatic efflux transporters at low micromolar concentrations.
Uses
CP 724714 is a HER-2 tyrosine kinase inhibitor used in tumor treatments for HER2 positive solid tumors.
Definition
ChEBI: CP-724714 is a 2-methoxy-N-[3-[4-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]anilino]-6-quinazolinyl]prop-2-enyl]acetamide in which the double bond adopts a trans-configuration. It is a potent inhibitor of HER2/ErbB2 (IC50 = 10 nM) and exhibits anti-cancer activity. It has a role as an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor, an antineoplastic agent, an apoptosis inducer and a hepatotoxic agent.